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PF 03716556

CAS No. 928774-43-0

PF 03716556( —— )

Catalog No. M16652 CAS No. 928774-43-0

PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF 03716556
  • Note
    Research use only, not for human use.
  • Brief Description
    PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively.
  • Description
    PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley rats (250 -300 g) treated with Pentagastrin Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg Administration:Intraduodenal administration; once Result:Inhibited gastric acid secretion in a dose-dependent manner.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    H+/K+-ATPase
  • Research Area
    Metabolic Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    928774-43-0
  • Formula Weight
    394.48
  • Molecular Formula
    C22H26N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 79 mg/mL (200.26 mM); DMSO: 79 mg/mL (200.26 mM)
  • SMILES
    CC1=C2[C@@H](CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mori, et al. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9.
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